Cystic fibrosis: The ‘bicarbonate before chloride’ hypothesis

نویسنده

Jeffrey J. Wine

چکیده

The specific effects of some mutations that cause cystic fibrosis suggest that reduced HCO(3)(-) transport is the key to understanding cystic fibrosis pathology. But there is a puzzling discrepancy between measures of CFTR-mediated chloride conductance in expression systems and the sweat chloride values of patients.

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